| Name - School | 2024 | 2025 | Improvement |
| Amoni Thompson - Walt Whitman | 1:06.19 | 1:00.45 | 5.74 |
| Juliana Riemersma - Moriah / Boquet Valley | 1:05.09 | 59.57 | 5.52 |
| Dorothy McMahon - Marcellus | 1:06.58 | 1:01.40 | 5.18 |
| Amira Hopson - Benjamin Banneker Academy | 1:06.35 | 1:01.20 | 5.15 |
| Nia Nelson - Saint Ann's School | 1:04.00 | 59.21 | 4.79 |
| Payton Richardson - Rye Country Day School | 1:02.10 | 57.86 | 4.24 |
| Aaliyah McDonald - Cicero-North Syracuse (CNS) | 1:05.04 | 1:00.94 | 4.10 |
| Lydia Semo - Cornwall | 1:03.74 | 59.80 | 3.94 |
| Ayla Felenstein - Rye Neck | 1:06.16 | 1:02.22 | 3.94 |
| Dylan Reisberg - North Shore | 1:06.62 | 1:02.74 | 3.88 |
| Cacie Beades - Eastchester | 1:06.39 | 1:02.53 | 3.86 |
| Breanne Barnett - V-Tesse Track Club of Long Island | 58.05 | 54.20 | 3.85 |
| Riley Flanagan - Burnt Hills-Ballston Lake | 1:05.42 | 1:01.57 | 3.85 |
| Chloe Beck - Minisink Valley | 1:06.39 | 1:02.58 | 3.81 |
| Mackenzie Ferrara - Massapequa | 1:06.65 | 1:02.85 | 3.80 |
| Emily Castillo - General Douglas MacArthur | 1:03.21 | 59.47 | 3.74 |
| Emily Chiosie - Monroe-Woodbury | 1:04.28 | 1:00.54 | 3.74 |
| Chase Cineus - St. Franci... |